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Interface Biologics Announces Sale of Surface Modification Business to Evonik

TORONTO, Canada, September 3, 2019 – Interface Biologics Inc. (“IBI”), a privately held, commercial stage developer of innovative material science technologies for Medtech and Pharmaceutical applications, is pleased to announce the sale of its surface modification business to Evonik (EVR: ETK), a German based specialty chemical company with revenues in excess of €13 billion in 2018.   The Health Care business line of Evonik, a leading supplier of products and services to the pharmaceutical, medical device and nutraceutical industries, will be running the business. The sale does not include IBI’s licensing agreement with Fresenius Medical Care for certain dialysis fields of use.

IBI’s surface modification business is centered around its Endexo® technology, patent protected macromolecules which enhance the biocompatibility of medical devices that come in contact with blood, tissue or other biological fluids.  These low molecular weight fluoro-oligomeric additives migrate to the top few nanometers of the devices surface without any changes required in the manufacturing process.  In the presence of blood, the modified surfaces are able to suppress procoagulant protein conformation, reduce platelet adhesion and inhibit platelet activation.  In the presence of bacteria mediated fluids, the modified surfaces are effective at reducing bacteria adhesion and encrustation.  Endexo® modified devices have been clinically proven to reduce infection and thrombus-related complications in FDA-cleared medical devices.  The Endexo® platform technology can be applied to a variety of base polymers and manufacturing techniques and become an integral part of the base material without compromising device functionality. 

“We are excited to onboard the Endexo® technology in our portfolio.” said Jean-Luc Herbeaux, SVP and General Manager of the Health Care business line of Evonik. “Endexo® expands our ability to serve as a development partner and solution provider to medical device companies worldwide. The team of Interface Biologics has done an exemplary job developing this innovative technology and bringing it to market. We look forward to applying our global business development capabilities and technical prowess to further expand the geographic and application footprint of Endexo®.”

“This is an exciting time for our organization”, stated Tom Reeves, President & CEO of Interface Biologics, Inc.  “The sale of our Surface Modification business to Evonik is the culmination of years of hard work in developing the underlying Endexo® technology and building value for our customers by improving the safety and effectiveness of their medical devices.  We have been working with Evonik on joint development opportunities over the last few years and I’m confident that the combination of our technology platform and the technical, commercial and financial resources of Evonik will allow us to accelerate the utilization of the Endexo® technology in broader sectors of the medical device market.  I’m proud that a major multinational player like Evonik has chosen to build on IBI’s expertise in surface modification by maintaining a presence in Toronto which is a testament to the capabilities of the entire local ecosystem.  I’m also excited about the continued progress with our Epidel® and Kinesyx® local drug delivery technology platforms and look forward to communicating specifics on our product development and financial strategies in the next few months.

October 15, 2024
TORONTO, CANADA / ACCESSWIRE / October 15, 2024 - Ripple Therapeutics Corporation, a clinical stage company focused on improving ophthalmic therapeutics with controllable sustained delivery implants, is pleased to announce evaluation and licensing agreements with Glaukos Corporation (NYSE: GKOS), an ophthalmic pharmaceutical and medical technology company focused on novel therapies for the treatment of glaucoma, corneal disorders and retinal disease. Ripple’s patented technology platform is based on a discovery that drugs can be chemically engineered into controlled release pharmaceuticals without the use of polymers or excipients. These proprietary prodrugs undergo surface erosion to give zero order release kinetics and are highly engineerable to tailor both drug dose and duration. The advantages of this technology include lower molecular weight and higher drug loading allowing for smaller implants and a lack of degradation products which provides both a clearer regulatory path as well as an improved safety profile. With an extended duration of therapeutic benefit, this technology will also reduce the treatment burden for patients. These agreements enable Glaukos to leverage Ripple’s proprietary technology platform to create sustained release implants of targeted APIs for both glaucoma and retinal diseases. If the program is successful, the evaluation agreement will automatically convert into a licensing agreement with future milestone payments and royalties. “We believe Ripple has one of the most promising drug delivery technologies currently under development,” commented Tomas Navratil, PhD, Chief Development Officer, Glaukos. “We are pleased with the progress of our collaboration and have enjoyed working with the Ripple team as we work together to bring these much-needed sustained release products to patients with critical unmet needs.” “This is the first of what we believe will be a number of transactions using our technology platform in concert with partners’ APIs to create sustained release implants which will benefit patients with extended duration and improved safety”, commented Tom Reeves, President & CEO, Ripple Therapeutics. “We look forward to continued collaboration with the entire Glaukos team.” About Ripple Therapeutics Ripple Therapeutics Corporation is a privately held clinical stage company focused on improving ophthalmic therapeutics with controllable sustained delivery implants. Ripple’s patented technology platform is based on a discovery that drugs can be chemically engineered into controlled release pharmaceuticals without the use of polymers or excipients. These proprietary prodrugs undergo surface erosion to give zero order release kinetics and are highly engineerable to tailor both drug dose and duration. The advantages of this technology include lower molecular weight and higher drug loading allowing for smaller implants and a lack of degradation products which provides both a clearer regulatory path as well as an improved safety profile. With an extended duration of therapeutic benefit, this technology will also reduce the treatment burden for patients. www.rippletherapeutics.com Media Contact (Ripple) Julie Fotheringham, V.P. Marketing, People & Culture, Ripple Therapeutics M: 416-951-7988 E: jfotheringham@rippletherapeutics.com
September 23, 2024
Hemal Mehta, MBBS, MD (Cantab.), presented Efficacy and safety of the low dose dexamethasone IBE-814 IVT Implant for diabetic macular edema and retinal vein occlusion: Results of a first-in-human Phase 2 trial, at Euretina Congress in Barcelona, Spain, September 19-22, 2024. View Presentation
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